Author

Ziyuan Fang

Howard Hughes Medical InstituteORCID 0000-0001-8679-6633Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Assay:DNA methylation· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Jack W. SzostakiD· 3 shared Xiwen JiaiD· 3 shared Dian DingiD· 1 shared Jahmyl EssexiD· 1 shared Lijun ZhouiD· 1 shared Orhan Acikgoz· 1 shared Ruby Wen· 1 shared Seohyun Chris KimiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

Jack W. SzostakORCID

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3 papers

Recent·Most cited

BiochemistryNucleic Acids ResearchPeer-reviewedNov 13, 2025

Impact of 2'-deoxyribo-purine substrates on nonenzymatic RNA template-directed primer extension

Ziyuan Fang, Orhan Acikgoz, Xiwen Jia…·Jack W. Szostak

This study examines how 2'-deoxyribo-purine substitutions affect RNA duplex stability and nonenzymatic template-directed primer extension.

DOI 10.1093/nar/gkaf1228

DNA methylationexperimental assay

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMay 21, 2025

Nonenzymatic RNA copying with a potentially primordial genetic alphabet

Ziyuan Fang, Xiwen Jia, Yanfeng Xing, Jack W. Szostak

This paper investigates a primordial genetic alphabet using 2-thiouridine (s2U), 2-thiocytidine (s2C), inosine (I), and adenine (A), showing that their base pairs are isoenergetic and isomorphic, enabling balanced nucleotide incorporation in nonenzymatic RNA copying.

3 citations

DNA methylationproteomics

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BiochemistryJournal of the American Chemical SocietyPeer-reviewedMay 31, 2024

Diaminopurine in Nonenzymatic RNA Template Copying

Xiwen Jia, Ziyuan Fang, Seohyun Chris Kim…·Jack W. Szostak

This study investigates whether replacing adenine with diaminopurine in nonenzymatic RNA template copying improves efficiency and reduces bias.

5 citations

DNA methylationexperimental assay

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