NeurosciencebioRxivPreprint
Stools and stool-derived extracellular vesicles from patients with Parkinson`s disease show alpha-4 synuclein seeding activity
Livia Civitelli, Poppy Stafford-Dorlandt, Kristijan D. Jovanoski…·Laura Parkkinen
This study shows that stool-derived extracellular vesicles from Parkinson's disease patients have alpha-synuclein seeding activity detectable by seed amplification assay, with improved sensitivity after pre-incubation with recombinant monomeric alpha-synuclein.
DOI 10.64898/2026.03.12.709633