Laura Parkkinen

GWAS on short tandem repeats identifies novel genetic mechanisms in Alzheimer's disease

This study conducts GWAS on short tandem repeats (STRs) to identify novel genetic mechanisms in Alzheimer's disease using data from ~330,000 individuals.

Stools and stool-derived extracellular vesicles from patients with Parkinson`s disease show alpha-4 synuclein seeding activity

This study shows that stool-derived extracellular vesicles from Parkinson's disease patients have alpha-synuclein seeding activity detectable by seed amplification assay, with improved sensitivity after pre-incubation with recombinant monomeric alpha-synuclein.

Epigenetic control of microglial developmental milestones from proliferative progenitors to efficient phagocytes

This study identifies a proliferative-to-quiescent switch in microglial development and links it to epigenetic regulation and phagocytic function.

Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases

The paper shows that LRRK2-mutant cases without Lewy bodies have abundant non-inclusion α-synuclein pathology detected by PLA, unlike Lewy body disease cases.

Identification of lncRNAs differentially expressed in Alzheimer's disease brains using RNA sequencing

The paper identifies differentially expressed lncRNAs in Alzheimer's disease brains using RNA-seq data from multiple studies and brain regions.

Unraveling Microglial Spatial Organization in the Developing Human Brain with DeepCellMap, a Deep Learning Approach Coupled to Spatial Statistics

The paper introduces DeepCellMap, a deep learning tool for analyzing spatial cellular organization in developing brains, revealing microglial phenotypes and spatial clustering patterns.

Rapid modulation of striatal cholinergic interneurons and dopamine release by satellite astrocytes

The paper reveals that striatal astrocytes rapidly modulate cholinergic interneurons and dopamine release through subsecond calcium dynamics in mice and humans.

Brain-derived and in vitro-seeded alpha-synuclein fibrils exhibit distinct biophysical profiles

The paper compares biophysical properties of brain-derived and in vitro-seeded alpha-synuclein fibrils from different synucleinopathies, finding structural and phosphorylation differences.

Development and validation of an expanded antibody toolset that captures alpha-synuclein pathological diversity in Lewy body diseases

The paper develops and validates an expanded antibody panel to capture diverse alpha-synuclein conformations and modifications in Lewy body diseases.

Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease

This study identifies four novel DNA methylation loci in the entorhinal cortex associated with Alzheimer's disease and finds significant epigenetic age acceleration in patients.

Identification of a sex-specific genetic signature in dementia with Lewy bodies: a meta-analysis of genome-wide association studies

This paper performs a large meta-analysis of GWAS in dementia with Lewy bodies, identifying sex-specific genetic risk signals and highlighting the need for larger cohorts.

Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders

The paper investigates astrocytic alpha-synuclein pathology in Lewy body disorders, revealing unique post-translational modification signatures and distribution patterns.

Common signatures of differential microRNA expression in Parkinson's and Alzheimer's disease brains

The paper assesses differential microRNA expression in Parkinson's and Alzheimer's disease brains, identifying shared miRNAs with potential pathogenic roles.

Differential microRNA expression analyses across two brain regions in Alzheimer's disease

The paper identifies differentially expressed miRNAs in two brain regions of Alzheimer's patients using qPCR and RNA-seq, highlighting potential targets involved in AD pathogenesis.

Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into the complex genetic architecture

This paper identifies five new genetic risk loci for Lewy body dementia through whole-genome sequencing and shows shared risk profiles with Alzheimer’s and Parkinson’s disease.

Heritability and genetic variance of dementia with Lewy bodies

This study estimates the heritability of dementia with Lewy bodies (DLB) and finds it to be higher than previous estimates, with low variance explained by polygenic risk scores from Parkinson's or Alzheimer's disease.

A comprehensive assessment of benign genetic variability for neurodegenerative disorders

The paper assesses benign genetic variability in elderly individuals without neurodegenerative disease to aid in distinguishing pathogenic mutations.