Sparse Epistatic Regularization of Deep Neural Networks for Inferring Fitness Functions
Amirali Aghazadeh, Hunter M. Nisonoff, Orhan Öçal, David H. Brookes, Yijie Huang, O. Ozan Koyluoglu, Jennifer Listgarten, Kannan Ramchandran
This paper introduces a method to improve deep neural network predictions of fitness functions by leveraging sparse epistatic interactions in genetic sequences.
Nature Communications · Sep 1, 2021Peer-reviewedBioinformatics