Weighted variance component test for the integrative multi-omics analysis of microbiome data
Angela Zhang, Wodan Ling, Amarise Little, Jessica S Williams-Nguyen, Jee‐Young Moon, Robert David Burk, Rob D. Knight, Dong D. Wang, Qibin Qi, Robert C. Kaplan, Ni Zhao, Michael C. Wu
The paper introduces a weighted variance components framework to integrate metagenomic and metabolomic data for pathway analysis, showing improved power while controlling type I error.
bioRxiv · Jun 14, 2024 · PreprintBioinformatics