Robert David Burk

Weighted variance component test for the integrative multi-omics analysis of microbiome data

The paper introduces a weighted variance components framework to integrate metagenomic and metabolomic data for pathway analysis, showing improved power while controlling type I error.

Kernel-based genetic association analysis for microbiome phenotypes identifies host genetic drivers of beta-diversity

The paper introduces a kernel-based method to identify host genetic variants associated with microbiome beta-diversity, finding immunity-related genes influence gut microbiota composition.

Large-scale association analyses identify host factors influencing human gut microbiome composition

The paper identifies 31 host genetic loci influencing gut microbiome composition through GWAS and suggests causal effects in inflammatory diseases.