Author

Roger C. Tam

Health CanadaORCID 0000-0002-4593-2587Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1 Assay:multiome· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Jon StoessliD· 1 shared Adele Dessa SadovnickiD· 1 shared Alexander RauscheriD· 1 shared Anthony L. TraboulseeiD· 1 shared David K.B. LiiD· 1 shared Francesco GentileiD· 1 shared François Émond· 1 shared Gaël Coulombe· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

A. Jon StoesslORCID

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2 papers

Recent·Most cited

Interconnecting ADC Structure with Tumor Cell Biology with Multimodal Learning

Hazem Mslati, Malcolm Wilson, Melika Naeinipour, Gaël Coulombe, Mehdi Ezzine, Tiana Yuen, Omar Abdal Bari, Hardeep Singh, Roger C. Tam, Joey G. Sheff, Francesco Gentile, Jeffrey Victor Leyton

The paper develops a multimodal machine learning framework to predict ADC cytotoxicity by integrating structural parameters with tumor cell biology data.

bioRxiv · May 27, 2026 · PreprintPharmacology & Toxicology

Cortical morphology predicts long-term placebo response in multiple sclerosis patients

Mariya V. Cherkasova, Jessie Fanglu Fu, Michael Jarrett, Poljanka Johnson, Shawna Abel, Roger C. Tam, Alexander Rauscher, Vesna Sossi, Shannon Kolind, David K.B. Li, Adele Dessa Sadovnick, Lindsay S. Machan, J. Marc Girard, François Émond, Reza Vosoughi, , A. Jon Stoessl

The paper examines how cortical morphology correlates with long-term placebo responses in multiple sclerosis patients, finding that non-responders have a more small-world-like cortical topology and lesion load inversely predicts cortical thickness in specific brain regions.

Scientific Reports · Jan 14, 2022Peer-reviewedNeuroscience