Author

Alessandra Biffi

Harvard UniversityORCID 0000-0002-4610-0870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Alberto PelosoiD· 1 shared Alice CaniiD· 1 shared Ana Zguro· 1 shared Anna Maria TestiiD· 1 shared Barbara BuldiniiD· 1 shared Carmelo RizzariiD· 1 shared Chiara Frasson· 1 shared Elena VarottoiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

Alberto PelosoORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintJun 19, 2026

Single-cell multiomic profiling reveals lineage plasticity in pediatric B-lineage Acute Lymphoblastic Leukemia during the early phase of treatment

Giulia Gomiero, Alberto Peloso, Elena Varotto…·Barbara Buldini

This study identifies lineage plasticity in pediatric B-lineage ALL during treatment by analyzing single-cell multiomic data from mmSW-positive and negative cases.

DOI 10.64898/2026.06.15.730052

humanscRNA-seq

NeuroscienceEMBO Molecular MedicinePeer-reviewedMar 6, 2023

An innovative hematopoietic stem cell gene therapy approach benefits CLN1 disease in the mouse model

Marco Peviani, Sabyasachi Das, Janki Patel…·Alessandra Biffi

This study demonstrates that gene therapy using hematopoietic stem cells can mitigate CLN1 disease symptoms in mice, with enhanced benefits from hPPT1 overexpression and combined transplantation approaches.

10 citations

mouseexperimental assay