Yoori Choi

Lymphatic drainage of cerebrospinal fluid using lymph node seeker 64Cu-labeled Gram-negative bacterial extracellular vesicles PET

The paper quantifies the lymphatic drainage of cerebrospinal fluid in mice using 64Cu-labeled bacterial extracellular vesicles and identifies cervical lymph nodes as the primary drainage sites.

Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy upon specific regional brain cells in mouse dementia model

The paper uses spatial transcriptomics to analyze brain cell changes in mouse dementia models after immunomodulation treatments and develops a new analysis tool.

Intrathecal Cu-albumin PET reveals age-related decline of cerebrospinal fluid (CSF)-lymphatic efflux

The paper uses [64Cu]Cu-albumin PET to quantify age-related decline in CSF-lymphatic efflux in mice, showing slower clearance and reduced lymph node activity in aged mice.

Spatiotemporal characterization of glial cell activation in an Alzheimer's disease model by spatially resolved transcriptome

This study characterizes spatiotemporal glial cell activation in an Alzheimer's disease model, revealing early white matter changes and later gray matter involvement.

Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer's disease model

This study shows that focused ultrasound with microbubbles improves beta-amyloid drainage in Alzheimer's model mice by enhancing brain-to-cerebrospinal fluid clearance.

Reconfiguration of neuronal subpopulation associated with disease-associated microglia in human Alzheimer’s disease brain

The study links disease-associated microglia enrichment to neuronal subtype reconfiguration, particularly in cortical layer 4 excitatory neurons, in Alzheimer's disease.