Population-level comparisons of gene regulatory networks modeled on high-throughput single-cell transcriptomics data.
Daniel Osorio, Anna Capasso, S. Gail Eckhardt, Uma P. Giri, Alexander J. Somma, Todd M. Pitts, Christopher Hanyoung Lieu, Wells A. Messersmith, Stacey M. Bagby, Harinder Singh, Jishnu Das, Nidhi Sahni, S. Stephen Yi, Marieke L. Kuijjer
This paper introduces SCORPION, a tool for reconstructing gene regulatory networks from single-cell RNA-seq data, showing it outperforms existing methods and detects consistent regulatory differences in colorectal cancer.
Nature Computational Science · Mar 4, 2024Peer-reviewedBioinformatics