Jason Harris

Precision neoantigen discovery using large-scale immunopeptidomes and composite modeling of MHC peptide presentation

This paper introduces SHERPA, a pan-allelic MHC-peptide prediction algorithm, which improves neoantigen discovery by integrating immunopeptidomics data and composite modeling.

Genomic loci susceptible to systematic sequencing bias in clinical whole genomes

The paper identifies genomic loci with systematic sequencing bias in clinical whole genomes and proposes a statistical method to flag suspect variants for quality control.

A variant by any name: quantifying annotation discordance across tools and clinical databases

This study evaluates variant annotation consistency across tools and databases, finding significant discordance in variant descriptions, particularly for insertions and deletions.