Thermo-Dynamic Flux Balance Analysis, a novel approach to simulate circadian metabolism
Gian Marco Messa, Peng Liu, Francesco Napolitano, Jesper N. Tegner, Xin Gao, Valerio Orlando
The paper introduces tdFBA, a novel method for simulating circadian metabolism across organs, and shows it can recapitulate metabolic oscillations and perturbations in mice and humans.
bioRxiv · Dec 19, 2025 · PreprintSystems Biology