Valerio Orlando

Endogenous retrotransposon activity supports osteocyte function and links antiretroviral therapy to bone loss

The paper shows that endogenous retrotransposon activity is linked to osteocyte function and bone health, and that antiretroviral drugs may impair this activity, contributing to bone loss.

Histone Succinylation-Driven LINE-1 Reactivation Links High-Fat Diet Stress to Hepatic Inflammation and Liver Disease

This study shows high-fat diet stress reactivates LINE-1 elements via histone succinylation, causing inflammation and liver disease, and suggests L1 inhibition as a therapeutic approach.

Thermo-Dynamic Flux Balance Analysis, a novel approach to simulate circadian metabolism

The paper introduces tdFBA, a novel method for simulating circadian metabolism across organs, and shows it can recapitulate metabolic oscillations and perturbations in mice and humans.

AGO1 interacts with NEAT1 lncRNA and impacts nuclear compartments

This study identifies a novel interaction between AGO1 and NEAT1 lncRNA, showing their roles in nuclear compartmentalization and chromatin organization.

Functional Annotation of Human Long Non-Coding RNAs via Molecular Phenotyping

The paper functionally annotates human long non-coding RNAs by systematically knocking down 285 lncRNAs and analyzing molecular phenotypes using CAGE sequencing.

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

RADICL-seq maps genome-wide RNA-chromatin interactions in intact nuclei, revealing general and cell type-specific patterns of transcript occupancy and the role of transcription in chromatin structure.

AGO1 in association with NEAT1 lncRNA contributes to nuclear and 3D chromatin architecture in human cells

This study shows AGO1 and NEAT1 lncRNA maintain 3D chromatin architecture by regulating TADs and A/B compartments in human cells.