Hemachander Subramanian

The paper develops a kinetics-based model for sequence-dependent DNA base selection fidelity and validates it against mutation spectra from mismatch repair-deficient organisms.

The paper shows that environmental changes alter proofreading enzyme rates, causing mutation supply fluctuations and evolutionary dynamics, with coding length and population size determining adaptation success.

The paper identifies a directional purine-pyrimidine asymmetry in CRISPR repeats that enhances spacer acquisition efficiency by promoting DNA unzipping kinetics.

This study identifies evolutionary pressures shaping genome size divergence between bacteria and eukaryotes by modeling replication time and information storage trade-offs.

The paper investigates whether genome size, replichore organization, and nucleotide skew predict bacterial growth rates, finding that skew improves predictive accuracy.

This paper presents a theoretical model of error correction in self-replicating systems that does not require enzymes or external energy, demonstrating kinetic discrimination and error ratios similar to biological processes.

This study develops a theoretical model showing eukaryotes increase genome size through multiple replication origins aided by endosymbionts, while prokaryotes minimize genome size due to single replication origins.