Koushik Ghosh

The paper develops a kinetics-based model for sequence-dependent DNA base selection fidelity and validates it against mutation spectra from mismatch repair-deficient organisms.

The paper shows that environmental changes alter proofreading enzyme rates, causing mutation supply fluctuations and evolutionary dynamics, with coding length and population size determining adaptation success.

This study identifies evolutionary pressures shaping genome size divergence between bacteria and eukaryotes by modeling replication time and information storage trade-offs.

The paper investigates whether genome size, replichore organization, and nucleotide skew predict bacterial growth rates, finding that skew improves predictive accuracy.