Author

Wern Juin Gabriel Ong

Fox Chase Cancer CenterORCID 0000-0002-4955-5205Unclaimed ORCID profile · follow to get notified of new preprints

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Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

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John KaranicolasiD· 1 shared Palani KirubakaraniD· 1 shared

Activity by Year

2023-2023 · peak 1/yr

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2 top collaborators · 1 mutual co-author link

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1 shared paperBioinformatics

John KaranicolasORCID

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1 paper

Recent·Most cited

Poor Generalization by Current Deep Learning Models for Predicting Binding Affinities of Kinase Inhibitors

Wern Juin Gabriel Ong, Palani Kirubakaran, John Karanicolas

This paper shows that current deep learning models for predicting kinase inhibitor binding affinities do not generalize well to unseen data, suggesting they rely on data leakage rather than learning molecular interactions.

bioRxiv · Sep 4, 2023 · PreprintBioinformatics