Author

Jordan Bryan

Broad InstituteORCID 0000-0002-4984-0516Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:machine learning (classical)· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Aviad TsherniakiD· 2 shared David E. RootiD· 2 shared Francisca VázqueziD· 2 shared James M. McFarlandiD· 2 shared Jesse S. BoehmiD· 2 shared Philip G. MontgomeryiD· 2 shared Todd R. GolubiD· 2 shared William C. HahniD· 2 shared

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2017-2025 · peak 1/yr

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2 shared papersGenomics

Aviad TsherniakORCID

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3 papers

Recent·Most cited

BioinformaticsbioRxivPreprintApr 30, 2025

Incorporating Large Language Model-Derived Information into Hypothesis Testing for Genomics

Jordan Bryan, Hongqian Niu, Didong Li

The paper introduces hypothesis tests using LLM-derived gene embeddings to improve statistical power in genomics studies.

1 citation

bulk RNA-seqstatistical model

𝕏 PostBluesky

GenomicsNature CommunicationsPeer-reviewedOct 29, 2018

Improved estimation of cancer dependencies from large-scale RNAi screens using model-based normalization and data integration

James M. McFarland, Zandra V. Ho, Guillaume Kugener…·Aviad Tsherniak

The paper improves gene dependency estimation from RNAi screens by using model-based normalization and data integration, enhancing accuracy and enabling cross-dataset analysis.

406 citationstop 1%

humanbulk RNA-seq

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GenomicsNature GeneticsPeer-reviewedOct 30, 2017

Computational correction of copy-number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells

Robin M. Meyers, Jordan Bryan, James M. McFarland…·Aviad Tsherniak

The paper develops CERES, a computational method to correct copy-number effects in CRISPR-Cas9 essentiality screens, improving specificity in cancer cell line studies.

1,951 citationstop 1%

humanCRISPR screen

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