Mutational signatures and increased retrotransposon insertions in Xeroderma Pigmentosum variant skin tumors
Camila Corradi, Juliana Brandstetter Vilar, Vanessa Candiotti Buzatto, Tiago Antônio de Souza, Ligia Pereira Castro, Veridiana Munford, Rodrigo De Vecchi, Pedro A. F. Galante, Fernanda Orpinelli Ramos do Rego, Thiago L. A. Miller, José Leonel Buzzo, Mírian Nacagami Sotto, Paulo Hilário Nascimento Saldiva, Jocelânio W. de Oliveira, Sulamita Costa Wirth Chaibub, , Carlos Frederico Martins Menck
The paper identifies mutational signatures and retrotransposon insertions in XP-V skin tumors, linking them to UV exposure and tobacco use, and suggests immunotherapy potential.
Carcinogenesis · May 17, 2023Peer-reviewedGenetic & Genomic Medicine