HTRA3 protease-chaperone stabilizes cathepsin B for mitochondrial POLG1 depletion in human cell ageing
Cristina Fernández Molina, Laurent Châtre, Benjamin Montagne…·Miria Ricchetti
The paper shows that HTRA3 stabilizes cathepsin B, leading to POLG1 degradation in ageing cells, with implications for progeroid disorders.