Author

Cheng Cheng

University of California, IrvineORCID 0000-0002-5007-4695Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Cheng Cheng2 papers · National Institutes of Health

Biology Disciplines

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Molecular Biology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Alyaa ShmaraiD· 3 shared Lan Nguyen WeissiD· 3 shared Pallabi PaliD· 3 shared Victoria Boock· 3 shared Virginia E. KimonisiD· 3 shared Jonathan LeeiD· 2 shared Lac TaiD· 2 shared Michele CarreriD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMolecular Biology

Alyaa ShmaraORCID

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3 papers

Recent·Most cited

GeneticsbioRxivPreprintAug 9, 2026

Characterization of the frameshift c.515dupC knock-in mouse model of HSPB8-associated myopathy (MFM13) and evaluation of Trehalose as autophagy modulating therapy.

Alyaa Shmara, Lan Nguyen Weiss, Anastasia Gromova…·Virginia E. Kimonis

This study characterizes a HSPB8 knock-in mouse model of MFM13 and evaluates trehalose as a potential autophagy modulating therapy for HSPB8-related myopathy.

DOI 10.64898/2026.08.04.742148

mouseproteomics

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Molecular BiologybioRxivPreprintJul 25, 2025

Antisense oligonucleotides targeting Valosin-containing protein improve muscle pathology and molecular defects in cell and mouse models of multisystem proteinopathy.

Pallabi Pal, Michele Carrer, Lan Nguyen Weiss…·Virginia E. Kimonis

This study shows that antisense oligonucleotides targeting VCP reduce disease pathology and improve muscle function in cell and mouse models of multisystem proteinopathy.

DOI 10.1101/2025.07.25.665261

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Molecular BiologyClinical and Translational MedicinePeer-reviewedApr 1, 2025

Skeletal muscle effects of antisense oligonucleotides targeting glycogen synthase 1 in a mouse model of Pompe disease

Lan Nguyen Weiss, Michele Carrer, Alyaa Shmara…·Virginia E. Kimonis

This study shows that ASO-mediated Gys1 knockdown in a mouse model of Pompe disease reduces glycogen accumulation and improves motor function, both alone and in combination with ERT.

4 citations

mouseexperimental assay

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