Author

Jessica N. Au

University of California San DiegoORCID 0000-0002-5043-2245Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:differential expression· 1 Organism:mouse· 1 Organism:rat· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Ludmil B. AlexandroviD· 2 shared Jiang Zhang· 1 shared Marcos Díaz-Gay· 1 shared Maria ZhivaguiiD· 1 shared Mariya KazachkovaiD· 1 shared Mark D. BarnesiD· 1 shared Peter T. Nguyen· 1 shared Raviteja VangaraiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenomics

Ludmil B. AlexandrovORCID

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2 papers

Recent·Most cited

A Compendium of 49 Experimental SBS Signatures for Decoding Human Cancer Mutational Processes

Maria Zhivagui, Jessica N. Au, Sanskruti Sharma, Peter T. Nguyen, Shams Al-Azzam, Jiang Zhang, Mark D. Barnes, Ludmil B. Alexandrov

The paper curates 49 experimental single-base substitution signatures from cancer genomes to link mutational processes to DNA damage mechanisms.

bioRxiv · Sep 4, 2026 · PreprintGenomics

The Impact of Variant Calling on Substitution Mutational Signature Inference

Zichen Jiang, Jessica N. Au, Mariya Kazachkova, Marcos Díaz-Gay, Raviteja Vangara, Ludmil B. Alexandrov

This study evaluates how variant calling strategies affect mutational signature inference, finding that consensus calling reduces artifacts while preserving true signals.

bioRxiv · Dec 12, 2025 · PreprintBioinformatics