Maria Zhivagui

A Compendium of 49 Experimental SBS Signatures for Decoding Human Cancer Mutational Processes

The paper curates 49 experimental single-base substitution signatures from cancer genomes to link mutational processes to DNA damage mechanisms.

SigRescueR: A Pan-System Framework for Noise Correction and Mutational Signature Identification Across Sequencing Platforms

SigRescueR corrects noise and identifies mutational signatures across sequencing platforms, revealing environmental and therapeutic mutagenic patterns in cancer genomes.

Multi-omics profiling reveals microenvironmental remodeling as a key driver of house dust mite-induced lung cancer progression

This study uses multi-omics profiling to show that house dust mite exposure accelerates lung tumor growth through immune-mediated mechanisms by altering the tumor microenvironment.

A Universal Duplex Sequencing Approach for Accurate Detection of Somatic Mutations

This paper introduces UDSeq, a duplex sequencing protocol for accurate somatic mutation detection with low DNA input and high coverage, achieving a low error rate and enabling cross-species profiling.

Experimental analysis of exome-scale mutational signature of glycidamide, the reactive metabolite of acrylamide

The paper identifies a unique mutational signature of glycidamide, a metabolite of acrylamide, through experimental and computational analysis, linking it to cancer genome patterns.