Preconceptional immunomodulation partially corrects pregnancy associated abnormalities induced by endometriosis in a mice model, with a normalization of transcriptional alteration observed in the developing fetal maternal interface at the single cell level.
Kheira Bouzid, Roxane Bartkowski, Alix SILVERT, Fabiana Moresi, Camille Souchet, Marine Thomas, Isabelle Lagoutte, Vaarany Karunanithy, Brigitte Izac, Charles Chapron, Piétro Santulli, Frédéric Batteux, Céline Méhats, Louis Marcellin, Ludivine Doridot
This study shows that preconceptional immunomodulation reduces pregnancy complications in a mouse model of endometriosis by partially reversing transcriptional changes in fetal-maternal interfaces.
bioRxiv · Mar 7, 2026 · PreprintMolecular Biology