Isabelle Lagoutte

This paper develops 3D preclinical models of β-catenin-driven liver cancers using organoids and tumouroids from mouse models, showing they preserve tissue features and respond to WNTinib treatment.

This study shows that preconceptional immunomodulation reduces pregnancy complications in a mouse model of endometriosis by partially reversing transcriptional changes in fetal-maternal interfaces.

This study shows that hepatocyte expression of fetal insulin receptor isoform INSR-A promotes liver cancer through non-cell autonomous mechanisms by increasing inflammation and enabling preneoplastic cell proliferation.