De novo generation of T-cell receptors with desired epitope-binding property by leveraging a pre-trained large language model
Jiannan Yang, Bing He, Yu Zhao, Feng Jiang, Zhonghuang Wang, Yixin Guo, Zhimeng Xu, Bo Yuan, Jiangning Song, Qingpeng Zhang, Jianhua Yao
The paper introduces ERTransformer, a large language model that generates T-cell receptors with desired epitope-binding properties, showing high functional similarity to natural TCRs.
bioRxiv · Oct 18, 2023 · PreprintBioinformatics