Retinal affectation in Huntington's disease mouse models concurs with a local innate immune response
Ana I. Arroba, Andrea Gallardo-Orihuela, Fátima Cano-Cano, Francisco Martín-Loro, María del Carmen González-Montelongo, Irati Hervás-Corpión, Pedro de la Villa, Lucía Ramón-Marco, Laura Gómez-Jaramillo, Luis Miguel Valor
The paper shows that retinal changes in HD mouse models mirror brain changes, including transcriptome rearrangement and neuroinflammation, supporting the retina as a model for HD research.
bioRxiv · Jan 17, 2023 · PreprintNeuroscience