Pedro de la Villa

This study evaluates MP-004, a novel FKBP12 ligand, showing improved retinal function and structure in retinitis pigmentosa models through protection against oxidative stress and cell death.

The paper shows that retinal changes in HD mouse models mirror brain changes, including transcriptome rearrangement and neuroinflammation, supporting the retina as a model for HD research.

This study shows that proinsulin activation of the insulin receptor preserves synapses and vision in retinitis pigmentosa by restoring signaling and synaptic connectivity.

This study shows HDAC inhibition delays cone death in RP mice by protecting multiple survival pathways, even after most rods have degenerated.

This paper generates two Nr2e3 mouse models using CRISPR-Cas9-D10A nickase to study retinal dystrophies, identifying a new short isoform and phenotypes resembling human RP and ESCS.