The impact of stroma on the discovery of molecular subtypes and prognostic gene signatures in serous ovarian cancer
Matthew Schwede, Levi Waldron, Samuel C. Mok, Wei Wei, Azfar Basunia, Melissa A. Merritt, Constantine S. Mitsiades, Giovanni Parmigiani, David P. Harrington, John F Quackenbush, Michael J. Birrer, Aedín C. Culhane
This paper shows that molecular subtypes and gene signatures in ovarian cancer are influenced by stromal cell content, suggesting that bulk tissue analysis may be unreliable without accounting for cell admixture.
Cancer Epidemiology Biomarkers & Prevention · Dec 23, 2019Peer-reviewedBioinformatics