Delaying Cancer Progression by Integrating Toxicity Constraints in a Model of Adaptive Therapy
Jana L. Gevertz, Harsh Vardhan Jain, Irina Kareva, Kathleen P. Wilkie, Joel S. Brown, Yitong Huang, Eduardo D. Sontag, Vladimir Vinogradov, Mark Davies
This paper develops a mathematical model to assess how incorporating toxicity feedback affects adaptive cancer therapy, finding that toxicity-induced treatment breaks can extend time to progression.
npj Systems Biology and Applications · Jan 7, 2026Peer-reviewedSystems Biology