PKD2L1 channels segregated to the apical compartment are the dual-mode pH sensor in cerebrospinal fluid-contacting neurons
Magdalena Vitar, Daniel Prieto, Stavros Malas, Raúl E. Russo, Federico Francisco Trigo
This study shows PKD2L1 channels in the apical process of CSFcNs are sensitive to pH changes, modulating neuronal excitability through both phasic and sustained currents.
eLife · Sep 21, 2026Peer-reviewedNeuroscience