Mechanistic Insights into ASO-RNA Complexation: Advancing Antisense Oligonucleotide Design Strategies.
Johanna Hörberg, Antonio Carlesso, Anna Reymer
This study uses molecular dynamics simulations to show that ASO-mRNA complex stability depends on ASO length, triple base pairs, and hairpin loop accessibility, offering insights for ASO design.
Molecular Therapy — Nucleic Acids · Oct 4, 2024Peer-reviewedBiophysics