GenomicsbioRxivPreprint
The Interplay between Mutagenesis and Extrachromosomal DNA Shapes Urothelial Cancer Evolution
Duy D. Nguyen, William F. Hooper, Timothy R. Chu…·Bishoy M. Faltas
This study examines how mutagenesis and extrachromosomal DNA contribute to urothelial cancer evolution, revealing clonal APOBEC3 mutations and chemotherapy-induced mutational bursts within ecDNA.
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