Adaptive-like features of the γδ TCR couple chronic BTNL recognition to NK-like tissue immunity
Benjamin D. McDonald, Hope D. Anderson, Toufic Mayassi, Chhon Ling Sok, Veronica Locher, Magdalena Justyniarska, Megan Borregard, Caroline Kaiser, Kristin Ladell, James E. McLaren, David A. Price, Narutoshi Hibino, Andrew S. Koh, Jamie Rossjohn, Benjamin S. Gully, , Bana Jabrì
This study shows how V{gamma}4 IELs use both germline and non-germline TCR features to sustain persistent BTNL3/8 recognition and express an NK-like program in the gut.
bioRxiv · Sep 24, 2026 · PreprintImmunology