Application of modular isoxazoline-β2,2-amino acid-based peptidomimetic foldamers as a chemical model system for studying the tau misfolding mechanism.
Davide Di Lorenzo, Nicolò Bisi, Raffaella Bucci, Inga Ennen, Leonardo Lo Presti, Veronica Isabel Dodero, Roland Brandt, Sandrine Ongeri, Maria Luisa Gelmi, Nicolò Tonali
This paper uses peptidomimetic foldamers to study tau misfolding by inducing specific conformations of PHF6 and PHF6* sequences, showing that extended conformations drive aggregation while β-hairpins prevent it.
iScience · Mar 22, 2025Peer-reviewedBiochemistry