Luis Javier Madrigal-Roca

GCM improves gene module detection by directly optimizing correlation-based metrics using a genetic algorithm, outperforming standard methods in synthetic and real data.

The paper examines codon usage bias and linked selection in Mimulus guttatus, finding weak codon selection for most genes and strong selection for specific functional genes, with linked selection affecting nucleotide diversity.

The paper uses experimental evolution to study micro-evolution in Mimulus guttatus under different mating systems and identifies genomic regions and candidate genes associated with selfing.