DeepSeMS: a large language model reveals hidden biosynthetic potential of the global ocean microbiome
Tingjun Xu, Yuwei Yang, Ruixin Zhu, Weili Lin, Jiqing Li, Yan Zheng, Peng Zhang, Guoqing Zhang, Guoping Zhao, Na Jiao
DeepSeMS uses a large language model to predict chemical structures of secondary metabolites from microbial gene clusters, outperforming existing methods and discovering novel compounds in the ocean microbiome.
bioRxiv · Mar 2, 2025 · PreprintSynthetic Biology