Large-scale RNA-seq mining reveals ciclopirox triggers TDP-43 cryptic exons
Irika R. Sinha, Parker S. Sandal, Grace D. Burns, Aswathy Peethambaran Mallika, Katherine E. Irwin, Anna Lourdes Cruz, Vania Wang, Josué Llamas Rodríguez, Philip C. Wong, Jonathan P. Ling
The paper uses large-scale RNA-seq data to show that ciclopirox triggers TDP-43 cryptic exon inclusion through oxidative stress and heavy metal toxicity.
bioRxiv · Mar 27, 2024 · PreprintNeuroscience