Systems BiologyeLifePeer-reviewed
Deep learning linking mechanistic models to single-cell transcriptomics data reveals transcriptional bursting in response to DNA damage
Zhiwei Huang, Songhao Luo, Zihao Wang…·Jiajun Zhang
This study introduces DeepTX, a deep learning framework that links mechanistic models to scRNA-seq data to infer transcriptional burst kinetics in response to DNA damage.