A pocket-centric framework for selective targeting of amyloid fibril polymorphs
Gaëtan Ossard, Constantin Bogdan Ciambur, Zachariah P. Schuurs, Ronald Melki, Olivier Spérandio, Eugénie Romero
The paper analyzes 400 cryo-EM structures of amyloid fibrils to identify shared and unique surface pockets, showing pocket-level convergence across polymorphs and proteins, and proposes a framework for selective ligand targeting.
bioRxiv · Jun 26, 2026 · PreprintBioinformatics