Olivier Spérandio

The paper analyzes 400 cryo-EM structures of amyloid fibrils to identify shared and unique surface pockets, showing pocket-level convergence across polymorphs and proteins, and proposes a framework for selective ligand targeting.

GTA-5 embeds protein binding pockets and ligands into latent spaces to enable structural reasoning, showing functional clustering and physicochemical property capture.

This study designs peptides targeting the FtsQBL divisome complex in E. coli using structure-guided methods, showing they inhibit cell division.

InDeep predicts functional binding sites in proteins for drug design on PPIs, outperforming existing tools on both PPI and conventional targets.