Iain S. Forrest

This study uses Mendelian randomization to identify causal effects of plasma triglycerides on 2,600 disease traits, finding 19 significant associations including cardiovascular and non-atherosclerotic diseases.

The paper constructs a tissue-level phenome-wide network map linking genes and phenotypes using colocalized signals from the UK Biobank and Genotype-Tissue Expression project.

This paper introduces MOI-Pred, a tool for predicting recessive inheritance of missense variants, showing high accuracy in distinguishing recessive disease-causing variants.

The paper quantifies disease risk associated with 37,772 clinical variants across 72,434 individuals, revealing heterogeneity in penetrance and limitations of current variant classification systems.