BiochemistrybioRxivPreprint
Secreted protein methyltransferase METTL9 catalyzes Nπ-histidine methylation of extracellular plasma proteins
N. Ikeda, Hiroaki Daitoku, Natsuki Odate…·Akiyoshi Fukamizu
The paper identifies METTL9 as the first secreted methyltransferase that catalyzes Nπ-histidine methylation of extracellular plasma proteins, establishing histidine methylation as the second extracellular post-translational modification.
DOI 10.64898/2025.12.23.696137