Specificity of Loxosceles α clade phospholipase D enzymes for choline-containing lipids: role of a conserved aromatic cage
Emmanuel E. Moutoussamy, Qaiser Waheed, Greta J. Binford, Hanif Muhammad Khan, Shane M. Moran, Anna R. Eitel, Matthew H. J. Cordes, Nathalie Reuter
The paper investigates the role of an aromatic cage in the lipid specificity of Loxosceles α clade phospholipase D enzymes using molecular dynamics simulations and experimental validation.
PLoS Computational Biology · Feb 18, 2022Peer-reviewedBioinformatics