Long Terminal Repeats of Gammaretroviruses Retain Stable Expression After Integration Retargeting or Knock-In into the Restrictive Chromatin of Lamina-Associated Domains
Dalibor Miklík, Martina Slavková, Dana Kučerová, Chahrazed Mekadim, Jakub Mrázek, Jiřı́ Hejnar
The paper shows that gammaretrovirus LTRs can drive stable gene expression even when integrated into restrictive chromatin domains like LADs using CRISPR-Cas9.
bioRxiv · May 30, 2024 · PreprintMolecular Biology