Differential brain atrophy and neurogenetic profiles in cognitively-defined Alzheimer's disease subgroups
Colin Groot, Michel J. Grothe, Shubhabrata Mukherjee, Irina Jelistratova, Iris E. Jansen, Anna Catharina van Loenhoud, Shannon L. Risacher, Andrew J. Saykin, Christine L. Mac Donald, Jesse B Mez, Emily H. Trittschuh, Gregor Gryglewski, Rupert R. Lanzenberger, Yolande A.L. Pijnenburg, Frederik Barkhof, , Rik Ossenkoppele
The paper identifies cognitive subgroups in Alzheimer's disease based on MRI-derived atrophy patterns and links them to specific biological pathways using transcriptomic data.
bioRxiv · Aug 4, 2020 · PreprintNeuroscience