Heterozygous Eif4nif1 Stop Gain Mice Replicate the Primary Ovarian Insufficiency Phenotype in Women
Mika Moriwaki, Lihua Liu, Emma Rae James, Neal D. Tolley, Ashley M O’Connora, Benjamin R. Emery, Kenneth Ivan Aston, Robert A. Campbell, Corrine Kolka Welt
This paper creates a mouse model with a stop-gain mutation in Eif4enif1 that replicates primary ovarian insufficiency in women, showing reduced follicle numbers and altered mRNA expression.
Endocrinology · Jan 18, 2025Peer-reviewedDevelopmental Biology