IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic Mechanisms
Bikash Mishra, Mahesh Bachu, Ruoxi Yuan, Claire K. Wingert, Vidyanath Chaudhary, Caroline Brauner, Richard D. Bell, Lionel B. Ivashkiv
This study identifies how IL-10 suppresses inflammatory gene expression by targeting IRF transcription factors and altering chromatin accessibility and histone marks in human monocytes.
Nature Immunology · Apr 22, 2025Peer-reviewedImmunology