Author

Mahesh Bachu

Hospital for Special SurgeryORCID 0000-0002-6494-6642Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

Bikash MishraiD· 2 shared Claire K. WingertiD· 2 shared Lionel B. IvashkiviD· 2 shared Caroline BrauneriD· 1 shared Richard D. BelliD· 1 shared Ruoxi YuaniD· 1 shared Vidyanath ChaudharyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersImmunology

Bikash MishraORCID

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2 papers

Recent·Most cited

ImmunologyNature ImmunologyPeer-reviewedApr 22, 2025

IL-10 Targets IRFs to Suppress IFN and Inflammatory Response Genes by Epigenetic Mechanisms

Bikash Mishra, Mahesh Bachu, Ruoxi Yuan…·Lionel B. Ivashkiv

This study identifies how IL-10 suppresses inflammatory gene expression by targeting IRF transcription factors and altering chromatin accessibility and histone marks in human monocytes.

79 citationstop 1%

humanChIP-seq

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ImmunologybioRxivPreprintNov 26, 2024

Epigenetic Regulation of Inflammatory NF-κB Target Genes by IFN-γ via IRF1

Bikash Mishra, Claire K. Wingert, Mahesh Bachu, Lionel B. Ivashkiv

This study shows IFN-γ enhances TLR-induced inflammatory gene expression through IRF1, which is critical for synergistic activation of genes like IL6 and TNF in human monocytes.

2 citations

humanbulk RNA-seq

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