Author

Devin W. Close

ARUP Institute for Clinical and Experimental PathologyORCID 0000-0002-6002-0471Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Anatasia Kellogg· 1 shared Bradley HalliD· 1 shared Brendan D. O’FalloniD· 1 shared Brian C. Haynes· 1 shared Bryan KillingeriD· 1 shared Connor A. ParkeriD· 1 shared Elizabeth S. BarrieiD· 1 shared Eric K. FredricksoniD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Anatasia Kellogg

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2 papers

Recent·Most cited

Multisite Evaluation of an Amplification-based Nanopore Sequencing Solution to Analyze Challenging Clinically Relevant Variants in Genes Associated with Hereditary Diseases

Stela Filipovic-Sadic, Connor A. Parker, Mia K. Mihailovic, John N. Milligan, Jonathan Turner, Stephanie L Borel, Vivian Le, Theodore Markulin, Justin Janovsky, Bryan Killinger, Malia J. Deshotel, N. Scott Reading, Eric K. Fredrickson, Yuan Ji, Devin W. Close, , Bradley Hall

This study evaluates a nanopore sequencing workflow for detecting complex variants in hereditary disease genes across multiple labs, finding high agreement with standard methods.

bioRxiv · May 19, 2026 · PreprintGenetics

Algorithmic improvements for discovery of germline copy number variants in next-generation sequencing data

Brendan D. O’Fallon, Jacob Durtschi, Anatasia Kellogg, Tracey B. Lewis, Devin W. Close, Hunter D. Best

This paper improves CNV detection in NGS data using algorithmic adaptations in an HMM framework, achieving better PPV with similar sensitivity compared to existing tools.

BMC Bioinformatics · Jul 19, 2022Peer-reviewedBioinformatics