Author

Luca Sesta

SIB Swiss Institute of BioinformaticsORCID 0000-0002-6051-0972Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Organism:virus· 2 Assay:whole-genome sequencing· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Richard A. NeheriD· 2 shared Angie S. HinrichsiD· 1 shared Chris Jennings-ShafferiD· 1 shared Frederick A. Matsen IViD· 1 shared Georg AngehrniD· 1 shared Hugh K. HaddoxiD· 1 shared Jared GallowayiD· 1 shared Jesse D. BloomiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersEvolutionary Biology

Richard A. NeherORCID

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2 papers

Recent·Most cited

Evolutionary BiologyGeneticsPeer-reviewedSep 17, 2026

Epistasis and the changing fitness landscapes of SARS-CoV-2

Luca Sesta, Richard A. Neher

The paper analyzes SARS-CoV-2 genomic data to show how mutational fitness costs change over time and introduces a model of pairwise epistasis to explain these changes.

DOI 10.1093/genetics/iyag227

viruswhole-genome sequencing

𝕏 PostBluesky

BioinformaticsNucleic Acids ResearchPeer-reviewedMay 29, 2025

The mutation rate of SARS-CoV-2 is highly variable between sites and is influenced by sequence context, genomic region, and RNA structure

Hugh K. Haddox, Georg Angehrn, Luca Sesta…·Richard A. Neher

The paper estimates mutation rates across SARS-CoV-2 genome sites and identifies factors influencing these rates, finding significant variability and patterns related to gene boundaries, sequence context, and RNA structure.

20 citationstop 1%

viruswhole-genome sequencing

𝕏 PostBluesky